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66 © Springer-Verlag Berlin Heidelberg 2005 32 Genetics RNA technologies are also a promising tool for the production of metabolites as cells can be grown to the desired growth phase. The use of the appropriate RNA technology can lead to product formation without necessarily having to shift to an inducing medium. Products that are growth inhibiting or, in the end, lethal for the cell, can even be synthesized when the fermentation process is broken down into separate growth and production phases.
38 Genetics All tRNAs are transcribed as precursors and need subsequent processing to generate mature 5’ and 3’ ends. Ribonuclease P removes a 5’ leader sequence from the precursor tRNA leaving a 5’-phosphate group. In contrast to eukaryotic RNase P, the RNA part in bacteria and archaea is able to recognize and cleave pre-tRNA without the protein compounds marking them as ribozymes. 3 The Ribosome Is a Ribozyme Ribosomes are huge aggregates containing three (four in eukaryotes) rRNA molecules and scores of protein molecules.
In connection with the truths of formal logic and mathematics. For whereas a scientific generalization is readily admitted to be fallible, the truths of mathematics and logic appear to be necessary and certain to everyone. But if empiricism is correct, no proposition which has a factual content can be necessary or certain. Accordingly, the empirist must deal with the truths of logic and mathematics in one of the two following ways: he must say either that they are not necessary truths, in which case he must account for the universal conviction that they are; or he must say that they have no factual content, and then he must explain how a proposition which is empty of all factual content can be true, useful, and surprising.