By Bengt Jonsell, T. Karlsson
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While transcriptomics exploits sequencespecific hybridization to capture specific transcripts and gives genuinely global coverage, the lack of an equivalent capture methodology for proteins has limited the extent to which the proteome can be interrogated. Emerging approaches such as aptamers or antibodies may eventually lead to protein chips that could approach the complete proteome [3], but this approach is still in the very early stages of development. Most current proteomic research instead relies on a combination of protein fractionation depending on physicochemical properties and protein identification by mass spectrometry [4].
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