By Christiana Ruhrberg
This publication is dedicated to vascular endothelial progress issue A (VEGF or VEGFA), a secreted signalling protein of significant importance for improvement and ailment in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it's consequently crucial for the institution of a sensible blood vessel circuit. furthermore, VEGFA is rising as a flexible patterning issue for numerous non-endothelial mobilephone kinds in vertebrates. hence, it performs a critical function in the course of organ improvement at a number of degrees, together with blood vessel progress, vessel-mediated organ induction and tissue differentiation.
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Additional resources for VEGF in Development (Molecular Biology Intelligence Unit)
Example text
Stimulation of endotheUal cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol 1996; l49(l):293-305. 9. Cleaver O, Krieg PA. VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus. Development 1998; 125(19):3905-3914. 10. Shalaby F, Ho J, Stanford WL et al. A requirement for Flkl in primitive and definitive hematopoiesis and vasculogenesis.
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