By Sudha K. Shenoy
Progress in Molecular Biology and Translational Science offers a discussion board for dialogue of latest discoveries, techniques, and concepts in molecular biology. It comprises contributions from leaders of their fields and ample references.
- Contains contributions from prime authorities
- Informs and updates on the entire newest advancements within the box
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Additional resources for Ubiquitination and Transmembrane Signaling
Example text
Rsp5 activity was suspected to involve adaptor proteins that function like β-arrestins in the mammalian cells. 221 These proteins are called ARTs or α-arrestins. 94 Thus, the three α-arrestins have specific effects and perhaps act on different conformational states of STE2. cerevisiae, an apparent glucose sensor (Gpr1), and an alkaline pH sensor (Rim21) remain to be defined. 3. 1 Overview As discussed in Section 2 and as listed in Table 1, ubiquitination serves as a regulatory signal at several checkpoints in the intracellular trafficking of an expanding number of GPCRs distributed across all the GPCR subfamilies.
The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome. J Biol Chem. 2010;285(48):37895–37908. 58. Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. J Biol Chem. 2009;284(9):5742–5752. 59. Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking.
Shenoy SK, Lefkowitz RJ. Beta-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci. 2011;32(9):521–533. 15. Claing A, Laporte SA, Caron MG, Lefkowitz RJ. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol. 2002;66(2):61–79. 16. Tian X, Kang DS, Benovic JL. Beta-arrestins and G protein-coupled receptor trafficking. Handb Exp Pharmacol. 2014;219:173–186. 17. Luttrell LM, Lefkowitz RJ. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.