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Systems Biology of Tumor Dormancy by Nava Almog PhD (auth.), Heiko Enderling, Nava Almog, Lynn

By Nava Almog PhD (auth.), Heiko Enderling, Nava Almog, Lynn Hlatky (eds.)

This quantity relies at the Workshop on structures Biology of Tumor Dormancy assembly, held July twenty fifth to July twenty eighth, 2011. the 1st annual CCSB workshop introduced jointly biologists, clinicians, mathematicians, and computing device scientists to debate numerous features of tumor dormancy and boost novel mathematical/computational types with the keynote audio system. particular subject matters incorporated the angiogenic swap, immune procedure interactions, melanoma stem cells and signaling.

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J Natl Cancer Inst 86(1):45–48 19. Goss P, Allan AL, Rodenhiser DI, Foster PJ, Chambers AF (2008) New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target? APMIS 116(7–8):552–568 20. Alsabti EA (1979) Tumor dormancy: a review. J Cancer Res Clin Oncol 95(3):209–220 21. Naumov GN, Folkman J, Straume O (2009) Tumor dormancy due to failure of angiogenesis: role of the microenvironment. Clin Exp Metastasis 26(1):51–60 22. Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization.

Nevertheless, the potential for macroscopic, post-vascular dormancy remains to be recognized in the general literature. , [13]), a state where the proximity to the precise tipping point of angiogenic induction is quite unclear (Fig. 1a, b). ” This is a form of clinically evident dormancy that, because it already possesses a vascular component poised to expand or shrink in response to even slight shifts in the angiogenic state of the microenvironment, is more arguably in a state of angiogenic balance (Fig.

6) which has two linearly independent solutions. 7) x From Eq. 8a) 2 27 The Host Support Niche as a Control Point for Tumor Dormancy... where A and B are constants. The constants are solved for by having the two solutions and their derivatives be continuous across the tumor boundary at r = r0. 8b) ⎛r c⎞ ⎛ r c ⎞⎞ s0 D ⎛ r0 c cosh ⎜ 0 ⎟ − sinh ⎜ 0 ⎟ ⎟ . ⎜ c c⎝ D ⎝ D ⎠ ⎝ D ⎠⎠ To assess the action of angiogenesis stimulators and inhibitors, we now take into account the relatively slow clearance of endogenous inhibitors and the relatively fast clearance of endogenous stimulators [15, 16, 38, 39].

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