By Richard D. Sontheimer M.D. (auth.), Marco Matucci-Cerinic, Daniel Furst, David Fiorentino (eds.)
Rheumatologic ailments are hugely linked to scientific indicators of the surface, nails, and mucosal membranes. This ebook presents the training rheumatologist with a speedy, effortless to refer to connection with support interpret the character of those cutaneous lesions after which quick select the right follow-up checks. using an abundance of informative images, it includes the entire crucial details wanted for early analysis and remedy. This accomplished consultant appropriately orients the practitioner in the tough international of rheumatologic issues of the surface and offers perception into whilst session with a dermatologist is really useful.
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1989;120:267–75. 9. Goette DK. Chilblains (perniosis). J Am Acad Dermatol. 1990;23:257–62. 10. Kuhn A, et al. Clinical manifestations in cutaneous lupus erythematosus. J Dtsch Dermatol Ges. 2007;5:1124–37. 11. Viguier M, et al. Clinical and histopathologic features and immunologic variables in patients with severe chilblains. A study of the relationship to lupus erythematosus. Medicine (Baltimore). 2001;80:180–8. 12. Lee-Kirsch MA, et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
An evenly distributed, fine pattern can be seen with intraluminal pathology, whereas a larger network with a patchy distribution is more characteristic of vasculitis or vessel wall pathology-associated LR. 2. Laboratory studies: The lupus anticoagulant panel should be considered in all patients with LR, given the common association and implications. , vasculitis, autoimmune or hematologic directed serologies). 3. Skin biopsy: Livedo reticularis without systemic associations does not require a skin biopsy.
Matucci-Cerinic et al. W. A. Vleugels Fig. 1. Differential Diagnosis Erythema ab igne is a heat-induced skin condition that begins as reversible LR and may become fixed with a reticulated pattern. Reticulated erythematous mucinosis may look similar to LR, but the primary morphology is of papules and plaques. It usually favors the mid trunk and is pruritic. , dermatomyositis, graft-versus-host disease, mycosis fungoides) can be confused with LR, but there will typically be epidermal change. Workup 1.