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Presbyopia Research: From Molecular Biology to Visual by Ana B. Chepelinsky, Eric F. Wawrousek, Robert A. Dubin,

By Ana B. Chepelinsky, Eric F. Wawrousek, Robert A. Dubin, Cynthia J. Jaworski (auth.), Gérard Obrecht, Lawrence W. Stark (eds.)

Seeing is existence. Seeing is transfonning luminous col­ we want to expand our educational and theoretical ored stimulations and shapes into amental represen­ wisdom and likewise to accomplish and trade our tation, based in house and in time. yet seeing is technical adventure to arrange additionally starting onto the realm that surrounds us: it's corrective potential for the longer term. hence a method for speaking and studying. quite a few questions have not begun to be replied, Jean-Jacques Rousseau, a thinker worthy equivalent to: quoting throughout the bicentennial of the French Revo­ lution of which he was once an instigator, acknowledged, "of all • Will it in the future be attainable to defer or cease the the senses, imaginative and prescient is that wh ich might be the least getting older of the accommodative equipment? comfortably separated from judgments of the brain. " • Is extra development of the present corrective Sight is more and more referred to as on in our smooth capacity attainable, no matter if spectacles or touch global. adulthood is affected at approximately 40-45 years by way of lenses? the on set of presbyopia. Atthat age, which calls for • How are behavioral and mental presbyope all our highbrow and actual skill, our sight typologies to be built-in during examination­ will be irreproachable. Our potency must never be ination, prescription, and becoming with corrective diminished.

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The slides were covered with a photographic emulsion and developed several days later. Top, I-day-old lens; bottom, I-month-old lens. , 1987). IfFGF is also stored in the lens capsule, does it control the accessibility of FGF cell surface receptors on epithelial cells that are attached to it? Is there a heterogeneity of lens capsule composition in the periphery and in the central part? CONCLUSION These data raise further questions about the mechanism of action of FGF in the eye in controlling lens growth.

The lens fiber possesses two other molecular forms of actin. One type corresponds to a water- 3 / DIFFERENTIATION OF LENS FIEERS 23 '. : . J . ;~ .. :. , '''. " . :=...... 2 p'm . "... FIGURE 3-1. lmmunotluorescence with (a) rhodamine-Iabeled phalloidin and (b) with tluorescein labeled antispectrin. Note the codistribution of actin and spectrin. (c) Isolated fiber ghost incubated with monospecific antibody against spectrin. The immunogold labeling reveals that spectrin is mostly associated with the cytoplasmic surface of the plasma membrane with the excIusion of the junctional domain (arrow).

Cell Biol. 43:479-486. , Lien, D. , and Benedetti, E. , 1985, Dilemmas of the structural and biochemical organization of lens membranes during differentiation and aging. Curr. Eye Res. 4(11):1219-1234. , and Benedetti, E. , 1987, Electron microscopic observations of reconstituted proteoliposomes with the purified major intrinsic membrane protein of eye lens fibers, J. Cell Biol. 105:1679-1689. Franke, W. , Kapprell, H. , 1987, Plakoglobin is a component of the filamentous subplasmalemmal coat of lens cells, J.

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