By Alexander Bürkle
Poly(ADP-Ribosyl)ation contains 19 chapters written by way of prime overseas specialists within the box and is richly illustrated. broad bibliography is given in every one chapter.
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Taken from Am~ et al,3with permission). 2 in human and 14 C1 in mouse consists of 16 exons and 15 introns spanning about 13 kilobase pairs (Fig. 2). Surprisingly, the PARP-2 gene lies head to head with the gene encoding the RNase P RNA subunit (H1 RNA). The distance between the transcription start sites of the PARP-2 and RNase P RNA genes is only 114 base pairs, suggesting that their regulation is coordinated through a bi-directional promoter. This unique promoter organization, conserved between human and mouse, allows an alternative gene expression mediated by RNA polymerase II (PARP-2) and by RNA polymerase III (HI RNA) since they share common transcriptional control elements.
Ame JC, Schreiber V, Fraulob V et al. A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene. J Biol Chem 2001; 276(14): 11092-9. 13. Doucet-Chabeaud G, Godon C, Brutesco C et al. Ionising radiation induces the expression of PARP-1 and PARP-2 genes in Arabidopsis. Mol Genet Genomics 2001; 265(6):954-63. 14. Oliver AW, Ame JC, Roe SM et al. Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.
Purified hTRF2 (100nM) was preincubated with the radiolabeled telomeric probe under binding conditions at 20°C, and purified mPARP-2 (100 nM) was subsequently added for 10 min (lanes 4 to 10), followed by the addition of NAD+ for various times as indicated, in the absence (lanes 4 to 9) or in the presence of 3-AB (lane 10). In lanes 1 to 3, the radiolabeled telomeric probe was incubated with respectively no protein, mPARP-2 or TRF2 for 30 min under binding conditions. When indicated, antibodies against PARP-2 (lane 8) or TRF2 (lane 9) were added after 30 min incubation under binding conditions.