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Mechanically Gated Channels and their Regulation by Charles G. Cranfield, Anna Kloda (auth.), Andre Kamkin, Ilya

By Charles G. Cranfield, Anna Kloda (auth.), Andre Kamkin, Ilya Lozinsky (eds.)

The quantity dwells at the significant problems with mechanical tension influencing the ion channels and intracellular signaling pathways. This ebook is a distinct selection of stories outlining present wisdom and destiny advancements during this quickly becoming box. In our opinion the ebook offers not just the most recent achievements within the box but in addition brings the matter towards the specialists in similar clinical and organic sciences in addition to working towards medical professionals. wisdom of the mechanisms which underlie those techniques is important for realizing of the conventional functioning of other dwelling organs and tissues and permits to foretell alterations, which come up because of adjustments in their setting, and probably will permit to boost new equipment of synthetic intervention. We additionally wish that proposing the matter will allure extra consciousness to it either from researchers and practitioners and should support to successfully introduce it into the sensible medicine.

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J Biol Chem 278(34):32246–32250 Mitra K, Ubarretxena-Belandia I, Taguchi T, Warren G, Engelman DM (2004) Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Nat Acad Sci 101(12):4083–4088 Moe P, Blount P (2005) Assessment of potential stimuli for mechano-dependent gating of MscL: effects of pressure, tension, and lipid headgroups. Biochemistry 44(36):12239–12244 Morris CE (1990) Mechanosensitive ion channels. J Membr Biol 113(2):93–107 Nomura T, Sokabe M, Yoshimura K (2006) Lipid-protein interaction of the MscS mechanosensitive channel examined by scanning mutagenesis.

In: Eaton SS, Eaton GE, Berliner L (eds) Biological magnetic resonance: Distance measurements in biological systems by EPR, vol 19. Kluwer Academic/Plenum Publishers, New York, pp 155–218 Meyer GR, Gullingsrud J, Schulten K, Martinac B (2006) Molecular dynamics study of MscL interactions with a curved lipid bilayer. Biophys J 91(5):1630–1637 Miller S, Bartlett W, Chandrasekaran S, Simpson S, Edwards M, Booth IR (2003a) Domain organization of the MscS mechanosensitive channel of Escherichia coli.

Biophys J 93(1):113–122 Powl AM, East JM, Lee AG (2008) Anionic phospholipids affect the rate and extent of flux through the mechanosensitive channel of large conductance MscL. Biochemistry 47(14):4317–4328 Reckel S, Sobhanifar S, Durst F, Löhr F, Shirokov VA, Dötsch V, Bernhard F (2010) Strategies for the cell-free expression of membrane proteins. In: Endo Y (ed) Cell-free protein production: 32 C. G. Cranfield et al. methods and protocols, methods in molecular biology, vol 607. Humana Press, New York, pp 187–212 Renner LD, Weibel DB (2011) Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes.

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