By Ana Sofia Pina, Abid Hussain, Ana Cecília A. Roque (auth.), Ana Cecília A. Roque (eds.)
Drug learn has been significantly reworked by way of the "omics revolution" and advances in computational instruments, combinatorial chemistry, and excessive throughput screening thoughts (HTS). those implements have complicated the facility to spot aim molecules that function issues of assault for destiny medicinal drugs, the layout and synthesis of capability lead compounds, and extra characterization, screening, and assays for healing efficacy and toxicity. In Ligand-Macromolecular Interactions in Drug Discovery: tools and Protocols, specialists within the box spotlight the most ideas and methodologies at present used in the examine of molecular interactions among compounds, both man-made or natural, and complementary organic objectives, in the scope of drug discovery. starting with a old point of view of drug examine concentrating on the contribution of genomics, proteomics, high-throughput equipment, and computational advancements in drug discovery, the booklet then delves into hugely certain equipment on issues equivalent to NMR spectroscopy, compound library layout and synthesis, chemical and organic microarrays, etc. Written within the hugely winning Methods in Molecular Biology™ sequence layout, chapters comprise introductions to their respective topics, lists of the required fabrics and reagents, step by step, simply reproducible protocols, and notes on troubleshooting and keeping off recognized pitfalls.
Authoritative and state-of-the-art, Ligand-Macromolecular Interactions in Drug Discovery: equipment and Protocols will function a fantastic consultant to scientists in academia and in who're striving to additional our wisdom of medicines.
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Extra info for Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols
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From narcosis to hyperspace: the history of QSAR. Quant. Act. Relat. 21, 348–356 50. Hansch, C. and Fujita, T. (1964). A method for the correlation of biological activity and chemical structure. J. Am. Chem. Soc. 86, 1616–1626 51. Kubinyi, H. (1997). QSAR and 3D QSAR in drug design. Part 1: methodology. Drug Discov. Today 2, 457–467 52. Kubinyi, H. (1997). QSAR and 3D QSAR in drug design. Part 2: applications and problems. Drug Discov. Today 2, 538–546 53. Good, A. , Mason, J. S. and Pickett, S.
1. 1. X-Ray Diffraction X-rays are scattered in all directions by the atoms present in a crystal, but only those waves that interfere constructively (according to Bragg’s law (see Note 4)) give rise to a diffracted beam, registered as diffraction spots (reflections) on a detector. Each reflection results from the interference of the X-rays diffracted from all the atoms in the crystal at the same diffraction angle. Therefore, each reflection contains information from all atoms in the structure. How then does one extract information about the position of each individual atom from the experimental diffraction data?
85, 3533–3539 37. Sabat, M. (1990). Ternary metal ion-nucleic acid base protein complexes. In: Sigel, H. and Sigel, A. ), Metal ions in biological systems. New York: Marcel Dekker, pp. 521 38. Friedman, H. L. (1951). Influence of isosteric replacements upon biological activity. N ASNRS 206, 295−358 39. Burger, A. (1991). Isosterism and bioisosterism in drug design. Prog. Drug. 37, 287–371 40. Langmuir, I. (1919). Isomorphism, isosterism, and covalence. J. Am. Chem. Soc. 41, 1543–1559 41. Patani, G.