By Ben HC Westerink, Thomas I.F.H. Cremers
Microdialysis is presently probably the most very important in vivo sampling tools in body structure and pharmacology. it really is used to figure out the chemical elements of the fluid within the extracellular area of tissues. The approach is now good verified in neuroscience examine and is used excessively in behavioral neuroscience to figure out the concentrations and identities of molecules in mind tissues, and their swap because of habit, hormonal and transmitter adjustments within the anxious method. The e-book presents an in depth complete evaluation of the expertise and its purposes, together with software in pathology, drug improvement, and the applying within the sanatorium. The authors are all renowned researchers in Neuroscience and specialists within the use of Microdialysis. geared up into elements of 7 sections, the guide of Microdialysis significantly examines fresh advancements within the box via numerous chapters written by way of an across the world acclaimed staff of authors. it's the first entire instruction manual masking the know-how of Microdialysis and its purposes in Neuroscience. * provides microdialysis equipment and interpretation together with the technical features of microdialysis as a sampling method via the analytical chemical equipment* Discusses the function of microdialysis in pharmacology, drug improvement and versions of CNS pathology* contains medical functions of microdialysis
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Additional info for Handbook of Microdialysis, Volume 16: Methods, Applications and Perspectives (Handbook of Behavioral Neuroscience)
Example text
Ungerstedt, U. and Fuxe, K. (1993) N-Methyl-D-aspartic acid differentially regulates extracellular dopamine, GABA, and glutamate levels in the dorsolateral neostriatum of the halothane-anesthetized rat: an in vivo microdialysis study. J. , 60: 1884–1893. , Takano, T. and Hansen, J. (2002) Beyond the role of glutamate as a neurotransmitter. Nat. Rev. , 3: 748–755. G. and Yamamoto, K. (1996) Concentration of extracellular L-glutamate released from cultured nerve cells measured with a small-volume online sensor.
2003) Extracellular glutamate increases in the lateral hypothalamus during meal initiation, and GABA peaks during satiation: microdialysis measurements every 30 s. Behav. , 117: 222–227. , Bianchi, R. and Pepeu, G. (1998) Neurotensin modulation of acetylcholine and GABA release from the rat hippocampus: an in vivo microdialysis study. Neurochem. , 33: 335–340. , Raiteri, M. and Bonanno, G. (2002) Coexistence and function of different neurotransmitter transporters in the plasma membrane of CNS neurons.
Spreading depression is a wave of glial and neuronal depolarization that propagates through the CNS and can lead to excitotoxic damage (Gorji, 2001). , 1999). N-acetyl aspartylglutamate (NAAG) is endogenous and abundantly expressed, and can be metabolized by NAALAdase inhibitors in the extracellular space to N-acetylaspartate and glutamate. This poses the possibility that NAAG hydrolysis may contribute to basal glutamate levels detected using microdialysis. , 1998). , 1999). These data illustrate that NAAG metabolism may contribute to pathogenic glutamate signaling during an ischemic event.