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Endothelin by Paul M. Vanhoutte, Thomas Gräser, Thomas F. Lüscher (auth.),

By Paul M. Vanhoutte, Thomas Gräser, Thomas F. Lüscher (auth.), Gabor M. Rubanyi M.D., Ph.D. (eds.)

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C. PANG, and R. M. RAPOPORT. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. J. Cardiovasc. Pharmacal. 13: S36-S44, 1989. 8. HOLDEN, W. , and E. McCALL. Hypoxic vasoconstriction of porcine pulmonary artery strips in vitro requires an intact endothelium. Am. Rev. Respir. Dis. 127: 301, 1983. 30 ENDOTHELIN 9. HOLDEN, W. , and E. McCALL. Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium. Exp. Lung Res. 7: 101-112, 1984.

RAPOPORT. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. J. Cardiovasc. Pharmacal. 13: S36-S44, 1989. 8. HOLDEN, W. , and E. McCALL. Hypoxic vasoconstriction of porcine pulmonary artery strips in vitro requires an intact endothelium. Am. Rev. Respir. Dis. 127: 301, 1983. 30 ENDOTHELIN 9. HOLDEN, W. , and E. McCALL. Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium. Exp. Lung Res. 7: 101-112, 1984. 10. HoM, G.

L. 2 •9 Exon 1 encodes the first 21 amino acids of preproendothelin, exon 2 encodes the mature endothelin-1 peptide and the first four amino acids of big endothelin, exon 3 encodes the "endothelin-like" peptide, exon 4 encodes residues 131-178 ofpreproendothelin, and exon 5 contains the sequence coding for the last 34 amino acids and the 3' untranslated region of preproendothelin. 2 ·9 The endothelin-1 transcription start site, mapped by S1 nuclease protection, is located 31 bp 3' of a TATAA box, 9 and a CAAT box is located 65 bp 5' to the TATAA box.

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