By Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
This ebook offers a accomplished evaluation of flow-based, microfluidic VLSI. The authors describe and resolve in a accomplished and holistic demeanour sensible demanding situations resembling keep an eye on synthesis, wash optimization, layout for testability, and prognosis of contemporary flow-based microfluidic biochips. They introduce useful ideas, in keeping with rigorous optimization and formal versions. The technical contributions awarded during this booklet won't simply shorten the product improvement cycle, but in addition speed up the adoption and additional improvement of contemporary flow-based microfluidic biochips, via facilitating the complete exploitation of layout complexities which are attainable with present fabrication techniques.
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Extra info for Computer-Aided Design of Microfluidic Very Large Scale Integration (mVLSI) Biochips
Example text
Madsen, Microfluidic Very Large Scale Integration (VLSI) (Springer, 2016) 67. html. Accessed 01 May 2016 68. A. Waldbaur, B. Carneiro, P. Hettich, E. E. Rapp, Computer-aided microfluidics (CAMF): from digital 3D-CAD models to physical structures within a day. Microfluid. Nanofluid. 15(5), 625–635 (2013) 69. Y. Zhao, K. Chakrabarty, Cross-contamination avoidance for droplet routing in digital microfluidic biochips. IEEE Trans. -Aided Des. Integr. Circuits Syst. 31(6), 817–830 (2012) 70. -Y. -W. Chang, Cross-contamination aware design methodology for pin-constrained digital microfluidic biochips.
C Routing after optimization for routability. 2 illustrates why all the three requirements discussed above must be considered carefully and in a global manner. In Fig. 2a, three sets of valves (red triangles, blue rectangles and green circles) are placed in a nine-by-nine grid. , at least three control pins are required. However, due to the interconnection of the green set, the minimization of control pins leads to an unroutable solution. , partition the green set into two (the green and violet sets in Fig.
Dunn, T. N. Smith, L. Esposito, S. E. J. S. , Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Res. 10(3), 330–343 (2000) 77. G. Kerkhoff, Testing microelectronic biofluidic systems. IEEE Design Test Comput. 1, 72–82 (2007) 78. T. Xu, K. Chakrabarty, Fault modeling and functional test methods for digital microfluidic biochips. IEEE Trans. Biomed. Circuits Syst. 3(4), 241–253 (2009) 79. Q. Al-Gayem, A. Richardson, H. Liu, N. Burd, An oscillation-based technique for degradation monitoring of sensing and actuation electrodes within microfluidic systems.