By Marco Baggiolini (auth.), Bernhard Moser, Gordon L. Letts, Kuldeep Neote (eds.)
The discovery of interleukin-8 on the subject of twenty years in the past initiated a brand new box of study concerning many elements of immunology and irritation. Interleukin-8 is only one member of a giant classification of structurally similar chemoattractant proteins, often called chemokines. Chemokines are enthusiastic about the site visitors regulate of leukocytes, which undergo the corresponding chemokine receptors on their surfaces. this present day, it really is transparent that chemokines have an effect on all features of immunology or even many unrelated fields, reminiscent of tissue improvement and tumor phone metastasis. Their primary contributions to continual inflammatory illnesses cause them to a significant goal for the advance of novel, anti inflammatory therapeutics.
This set of books* provides a state of the art account of contemporary advancements during this box within the type of summaries written via very hot specialists. quantity I is targeted on simple rules and growth in chemokine biology, and quantity II offers with matters with regards to chemokine-related drug improvement and power healing purposes. those volumes offer either introductory and novel info for a vast readership, together with clinicians and biomedical scientists.
*See additionally okay. Neote/G.L. Letts/B. Moser, Chemokine Biology - simple examine and medical software. quantity II: Pathophysiology of Chemokines. 2006, Birkhäuser, growth in irritation examine, ISBN 3-7643-7195-1.
Read or Download Chemokine Biology — Basic Research and Clinical Application: Volume I: Immunobiology of Chemokines PDF
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The invention of interleukin-8 on the subject of twenty years in the past initiated a brand new box of study referring to many elements of immunology and irritation. Interleukin-8 is only one member of a giant classification of structurally comparable chemoattractant proteins, often called chemokines. Chemokines are concerned with the site visitors keep an eye on of leukocytes, which endure the corresponding chemokine receptors on their surfaces.
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Extra resources for Chemokine Biology — Basic Research and Clinical Application: Volume I: Immunobiology of Chemokines
The integrin αEβ7 discriminates between LN- and inflamed tissue-homing Treg cells, and the latter subset was found to contain the most potent suppressors of inflammatory processes in disease models, such as antigen-induced arthritis . Early studies showed that circulating and thymic human Treg cells expressed CCR4 and/or CCR8 [65, 66] but, clearly, chemokine receptors do not discriminate between Treg cells and pro-inflammatory T cells. The definitions of the migration patterns associated with distinct Treg cells will largely depend on the discovery of reliable markers for these cells.
In clear contrast to the T zone chemokines CCL19 and CL21, the single CXCR5 ligand CXCL13 is selectively produced within the B cell compartment, suggesting that the acquisition of CXCR5 by recently primed CD4+ T cells would drive their relocation to the B cell follicles (Fig. 1). Indeed, several studies have documented a temporary relocation of T cells to the outer edge of the follicles in response to immunisation [27, 28]. In mice, follicular migration of primed T cells occurs rapidly after immune response initiation, well before the generation of effector T cells [21, 28], and this observation fully agrees with the kinetics of CXCR5 expression on human T cells.
The best understood examples of 27 Charles R. Mackay and Bernhard Moser tissue-selective homing are related to T cell traffic in the skin and gut, but migration selectivity for other organs, such as the lung or joints, may also exist. As discussed above, the adhesion molecules or chemokine receptors responsible for tissue migration are either absent from naïve T cells or are expressed at low levels. Moreover, distinct subsets of memory T cells are definable by adhesion molecules or chemokine receptors.