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Cellular and Molecular Biology of Atherosclerosis by W. C. Roberts (auth.), Antonio M. Gotto Jr MD, DPhil (eds.)

By W. C. Roberts (auth.), Antonio M. Gotto Jr MD, DPhil (eds.)

Atherosclerotic heart problems continues to be the foremost reason behind dying and incapacity in Western society. the sphere of atherosclerosis learn has grown significantly during the last 40 years, laying off loads of gentle at the contributing components and usual heritage of the disease and allowing innovations for its remedy and prevention. the various maximum strides during this box lately have derived from advances in molecular biology options. those strides have been selected for emphasis within the latest Princess Lilian symposium, whose court cases this quantity represents. traditionally, the Princess Lilian conferences were small ones geared toward bringing jointly investigators from varied specialties to debate a selected topic. the latest assembly was once no exception and incorporated clinicians, scientific investigators, and learn­ ers in uncomplicated technology. The symposium started with an in depth evaluation of coronary morphopathological findings in sufferers who died of heart sickness. Any rational speculation of atherogenesis needs to keep in mind medical findings, and any try to bridge the space among experimental laboratory findings and experiences in guy is very fascinating. 3 chapters specialise in endothelial damage: one at the nitric oxide pathway in body structure and pathology, a moment at the activation of endothelial cells, and a 3rd at the monocyte and endothelial damage. nonetheless one other bankruptcy examines progress elements, particularly the fibroblast progress think about atherogenesis.

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J Surg Res 28:151-170 Hoffman SL, Punjabi NH, Kumala S, Moechtar MA, Pulungsih SP, Rivai AR, Rockhill RC, Woodward TE, Loedin AA (1984) Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med 310:82-88 Hutcheson IR, Whittle BJR, Boughton-Smith NK (1990) Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 101: 815-820 Ignarro U, Buga GM, Wood KS, Byrns RE, Chaudhuri G (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Br J Pharmacol 88:411-415 Billiar TR, Curran RD, Stuehr DJ, West MA, Bentz BG, Simmons RL (1989) An L-arginine dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J Exp Med 169:1467-1472 References 31 Billiar TR, Curran RD, Stuehr DJ, Stadler J, Simmons RL, Murray SA (199Oa) Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes. Biochem Biophys Res Commun 168: 1034-1040 Billiar TR, Curran RD, Stuehr DJ, Hofmann K, Simmons RL (1990b) Inhibition of L-arginine metabolism by ,vo-monomethyl-L-arginine in vivo promotes hepatic damage in response to lipopolysaccharide.

1990; Rees et al. 1990a). In one of these studies (Tolins et al. 1990), the vasodilatation induced by ACh was accompanied by an increase in the urinary excretion of cyclic GMP, both of which were prevented by L-NMMA. The effects of L-NMMA on blood pressure were also associated with a decrease in glomerular filtration rate. The increase in blood pressure induced by L-NMMA was also associated with a decrease in vascular conductance in the renal, mesenteric, carotid and hindquarters vascular beds of conscious, chronically instrumented rats (Gardiner et al.

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