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Additional resources for Cell Physiology (LANGE Physiology Series)
The membrane conductance for ion x is gx. 3] The conductance is proportional to the permeability of the membrane or the ease with which ions move through it. The conductance is also proportional to the concentration of the conducting ion(s). In the absence of sodium ions, a sodium channel may be permeable (if it is open), but it will not conduct any current. The voltage gradient pushes or pulls an ion because the ion is charged. The concentration gradient is a conjugate force; ions tend to move from a high concentration to a low concentration.
Water Transport Life is intimately associated with the movement of water. Our bodies are mostly water and are vitally dependent on its continual supply. Water is a small but abundant molecule. 2 nm across— small enough to intercalate between other molecules, even in some crystals. A mole of water is 18 mL; thus pure water is 55 mol/L. Because the molecules are small, they move easily. Because they are so abundant, their movements are important to our well-being. The death of infants by dehydration subsequent to diarrhea is a health problem in many parts of the world.
If a cell is damaged, it can close its cell-cell channels leading to its neighbors and thus prevent the loss of small molecules from the whole tissue. This gating is controlled by intracellular Ca2+, H+, or transjunctional voltage. Different connexons have relatively different sensitivity to these three changes. Gating can also be induced by octanol and anesthetics such as halothane. PUMPS Ions move across cell membranes via channels, pumps, and transporters. These are three fundamentally distinct mechanisms and the student should be careful not to confuse them.