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The Liver: Biology and Pathobiology, Fifth Edition by -Author-

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Content material:
Chapter 1 Organizational rules of the Liver (pages 1–15): Joe W. Grisham
Chapter 2 Embryonic improvement of the Liver (pages 17–25): Roque Bort and Kenneth S. Zaret
Chapter three Microtubules, Actin Filaments and Motor?Mediated Vesicular shipping (pages 27–43): Ronald R. Marchelletta and Sarah F. Hamm?Alvarez
Chapter four Molecular cars (pages 45–55): Peter Satir
Chapter five Ion Pumps and Molecular vehicles: P?, F?, and V?type ATPases (pages 57–71): Sarah Bond, Daniel J. Cipriano and Michael Forgac
Chapter 6 Hepatocyte floor Polarity: Its Dynamic upkeep and institution (pages 73–105): Lelita T. Braiterman and Ann L. Hubbard
Chapter 7 Endocytosis as a vital approach in Liver functionality and Pathology (pages 107–123): Barbara Schroeder and Mark McNiven
Chapter eight Membrane shipping in Hepatocellular Secretion (pages 125–135): Susan Chi and Mark McNiven
Chapter nine Mitochondria (pages 137–146): Kasturi Mitra
Chapter 10 Nuclear Pore complicated (pages 147–155): Joseph S. Glavy
Chapter eleven Protein Maturation and Processing on the Endoplasmic Reticulum (pages 157–171): Ramanujan S. Hegde
Chapter 12 Protein Degradation and the Lysosomal approach (pages 173–189): Susmita Kaushik and Ana Maria Cuervo
Chapter thirteen Peroxisome meeting, Degradation, and ailment (pages 191–200): Peter ok. Kim
Chapter 14 hole and Tight Junctions in Liver: Composition, rules, and serve as (pages 201–220): Takashi Kojima, Norimasa Sawada, Hiroshi Yamaguchi, Alfredo G. citadel and David C. Spray
Chapter 15 Copper Metabolism and the Liver (pages 221–233): Michael L. Schilsky and Dennis J. Thiele
Chapter sixteen The principal function of the Liver in Iron garage and legislation of Systemic Iron Homeostasis (pages 235–250): Tracey A. Rouault, Victor Gordeuk and Gregory Anderson
Chapter 17 issues of Bilirubin Metabolism (pages 251–256): Namita Roy Chowdhury and Jayanta Roy Chowdhury
Chapter 18 Hepatic Fatty Acid Metabolism and disorder (pages 257–270): David L. Silver
Chapter 19 Lipoprotein Metabolism and ldl cholesterol stability (pages 271–285): David E. Cohen
Chapter 20 Bile Acids and the Enterohepatic flow (pages 287–304): Alan F. Hofmann
Chapter 21 Hepatocyte Basolateral Membrane natural Anion Transporters (pages 305–321): Jo H. Choi, John W. Murray and Allan W. Wolkoff
Chapter 22 Nuclear Receptors keep an eye on Bile Acid Synthesis (pages 323–337): Guorong Xu and Gerald Salen
Chapter 23 The functionality of the Canalicular Membrane in Bile Formation and Secretion (pages 339–348): Ronald P. J. Oude Elferink and Coen C. Paulusma
Chapter 24 Apical Recycling of Canalicular ABC Transporters (pages 349–358): Yoshiyuki Wakabayashi and Irwin M. Arias
Chapter 25 Cholangiocyte capabilities in wellbeing and fitness and illness: The Ciliary Connection (pages 359–369): Anatoliy I. Masyuk, Tatyana V. Masyuk and Nicholas F. Larusso
Chapter 26 The Hepatic Sinusoidal Endothelial cellphone: Morphology, functionality, and Pathobiology (pages 371–388): Laurie D. Deleve
Chapter 27 Fenestrations within the Liver Sinusoidal Endothelial phone (pages 389–406): Victoria C. Cogger and David G. Le Couteur
Chapter 28 Hepatic Stellate Cells (pages 407–432): Marcos Rojkind and Karina Reyes?gordillo
Chapter 29 Hepatic Fibrosis (pages 433–452): Ram?on Bataller and David A. Brenner
Chapter 30 Matrix (pages 453–467): Giuliano Ramadori and Jozsef Dudas
Chapter 31 Insulin Resistance (pages 469–483): Varman T. Samuel, Kitt F. Petersen and Gerald I. Shulman
Chapter 32 Ca2+ Signaling within the Liver (pages 485–510): Fatima M. Leite, Mateus T. Guerra and Michael H. Nathanson
Chapter 33 position of Intracellular Iron move and Oxidant tension in Hepatocellular damage (pages 511–520): John J. Lemasters, Akira Uchiyama, Jae?Sung Kim, Kazuyoshi Kon and Hartmut Jaeschke
Chapter 34 Regulatory Pathways of Liver Gene Expression: The relevant function of Cyclic AMP (pages 521–534): Giuseppe Servillo, Maria Agnese Della Fazia and Paolo Sassone?Corsi
Chapter 35 AMPK: primary Regulator of Glucose and Lipid Metabolism (pages 535–548): Maria M. Mihaylova and Reuben J. Shaw
Chapter 36 Liver Regeneration (pages 549–565): Nelson Fausto and Jean S. Campbell
Chapter 37 Ribosome Biogenesis and its position in mobilephone development and Proliferation within the Liver (pages 567–575): Stefano Fumagalli and George Thomas
Chapter 38 Liver Repopulation via mobile Transplantation and the position of Stem Cells (pages 577–595): David A. Shafritz, Michael Oertel, Mariana D. Dabeva and Markus Grompe
Chapter 39 Hepatic Encephalopathy (pages 597–617): Roger F. Butterworth and Javier Vaquero
Chapter forty The Kidney in Liver affliction (pages 619–638): Moshe Levi
Chapter forty-one serious position of the Liver in Coagulation (pages 639–658): Robert Fathke, Ze Peng, Basil Golding and Chava Kimchi?Sarfaty
Chapter forty two Inheritable Cholestatic problems (pages 659–679): Paul Gissen and A. S. Knisely
Chapter forty three Adaptive law of Hepatocyte Transporters in Cholestasis (pages 681–702): James L. Boyer
Chapter forty four Pathogenesis of Portal high blood pressure (pages 703–717): Roberto J. Groszmann and Juan G. Abraldes
Chapter forty five Non?Alcoholic Fatty Liver affliction: A Pathophysiological viewpoint (pages 719–741): Michael Fuchs and Arun J. Sanyal
Chapter forty six Pathophysiology of Alcoholic Liver illness (pages 743–772): Natalia Nieto and Marcos Rojkind
Chapter forty seven irritation and Drug?Induced Liver damage (pages 773–781): Robert A. Roth and Patricia E. Ganey
Chapter forty eight Hepatocyte Apoptosis (pages 783–802): Cynthia R. L. Webster
Chapter forty nine again to the long run: A Backward look on the ahead development of Hepatitis Virus learn (pages 803–806): Harvey J. Alter
Chapter 50 Molecular Biology of Hepatitis Viruses (pages 807–834): Christoph Seeger, Michael M. C. Lai and William S. Mason
Chapter fifty one Immune Mechanisms of Viral Clearance and illness Pathogenesis in the course of Viral Hepatitis (pages 835–857): Carlo Ferrari and Mario Mondelli
Chapter fifty two medical Implications of the Molecular Biology of Hepatitis B Virus (pages 859–876): Timothy M. Block, Ju?Tao Guo and W. Thomas London
Chapter fifty three Viral get away Mechanisms in Hepatitis C and the medical outcomes of chronic an infection (pages 877–897): Stanley M. Lemon, Patrizia Farci and Marc G. Ghany
Chapter fifty four present and destiny treatment for Hepatitis B and C (pages 899–919): Gary L. Davis and Jean?Michel Pawlotsky
Chapter fifty five organic ideas and medical matters Underlying Liver Transplantation for Virus?Induced End?Stage Liver illness (pages 921–931): James R. Burton, Hugo R. Rosen and Paul Martin
Chapter fifty six Tissue Engineering of the Liver (pages 933–953): Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia
Chapter fifty seven getting older and the doubtful Roles of Sirtuins (pages 955–960): J. Fred Dice
Chapter fifty eight The Liver Proteome (pages 961–963): Laura Beretta
Chapter fifty nine Liver?Directed Gene treatment (pages 965–990): Betsy T. Kren, Clifford J. Steer, Namita Roy Chowdhury and Jayanta Roy Chowdhury
Chapter 60 deciphering the Liver melanoma Genome (pages 991–997): Ju?Seog Lee and Snorri S. Thorgeirsson
Chapter sixty one Genome?Wide Expression Profiling of Human Hepatocellular Carcinoma (pages 999–1013): Anuradha Budhu and Xin Wei Wang
Chapter sixty two mobile Cycle regulate within the Liver (pages 1015–1027): Jeffrey H. Albrecht and Lisa ok. Mullany
Chapter sixty three miRNAs and Liver Biology (pages 1029–1052): Charles E. Rogler and Leslie E. Rogler
Chapter sixty four Imaging mobile Proteins and buildings: Smaller, Brighter, and speedier (pages 1053–1066): Erik Snapp
Chapter sixty five Zebrafish as a version process for the examine of Liver improvement and ailment (pages 1067–1074): Randolph P. Matthews
Chapter sixty six The Hepatocyte and the melanoma mobile: Dr Jekyll and Mr Hyde (pages 1075–1090): Jean?Pierre Gillet, Michael M. Gottesman and Mitsunori Okabe
Chapter sixty seven The function of Endocannabinoids and Their Receptors within the keep an eye on of Hepatic services (pages 1091–1103): George Kunos, Douglas Osei?Hyiaman, Sandor Batkai, good friend Pacher, Bin Gao, Won?Il Jeong, Jie Liu and Gregorz Godlewski
Chapter sixty eight Telomeres and getting older, melanoma, and Hepatic Fibrosis (pages 1105–1119): Hans L. Tillmann, Ruben R. Plentz, Yvonne Begus?Nahrmann, Andree Lechel and Lenhard okay. Rudolph
Chapter sixty nine remedy of Cirrhosis with diet A?Coupled Liposomes sporting siRNA opposed to warmth surprise Protein (pages 1121–1129): Yoshiro Niitsu, Yasushi Sato, Kazuyuki Murase and Junji Kato
Chapter 70 The “Green Liver” and Transcriptional law of part II detoxing Genes (pages 1131–1138): Christopher Johnson and Jonathan Arias

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Extra info for The Liver: Biology and Pathobiology, Fifth Edition

Sample text

About 35% of the total hepatocyte surface faces sinusoids, and the area of this surface is greatly amplified by the folding of the plasma membrane to form innumerable microvilli that extend into the space of Disse [63]. About 50% of the total hepatocyte surface faces adjacent hepatocytes [63]. The plasma membrane of these intercellular surfaces is mostly flat except where it is infolded to form bile canaliculi, which comprise about 13% of the total hepatocyte surface [63], also amplified by microvilli.

These functions include the metabolic activities of both phase I (CYP450) and phase II (conjugation) enzymes measured via fluorimetric (Bfc, Mfc, coumarin, 7-hc) and conventional probe substrates (bupropion HCL and testosterone). Enzyme activities in micropatterned co-cultures at baseline (uninduced) are shown over several weeks, with pure hepatocytes on day 0 (6 hours after plating) and day 11 included for comparison. Arrows pointing to the x -axis indicate undetectable substrate metabolism in pure hepatocytes on day 11.

The unique structure of liver endothelium and sinusoids enables the free escape of fluid components of blood, but the matrix molecules located in the space of Disse can bind some molecules ([71] and 10 THE LIVER: FUNCTIONAL AND STRUCTURAL HETEROGENEITY ALONG HEPATIC PLATES AND SINUSOIDS references therein) and may retard the access of some solutes to hepatocyte surfaces. Sinusoidal endothelial cells are actively pinocytic and avidly clear effete proteins and colloids from the perfusing blood through several scavenger receptors, providing the main pathway for clearance of effete molecules from the circulation [69, 72].

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