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Biomedical EPR, Part A: Free Radicals, Metals, Medicine, and by Helmut Beinert (auth.), Sandra R. Eaton, Gareth R. Eaton,

By Helmut Beinert (auth.), Sandra R. Eaton, Gareth R. Eaton, Lawrence J. Berliner (eds.)

Biomedical EPR – half A specializes in purposes of EPR spectroscopy within the parts of unfastened radicals, metals, drugs, and body structure. The ebook celebrates the 70th birthday of Prof. James S. Hyde, scientific collage of Wisconsin, and his contributions to this box. Chapters are written to supply introductory fabric for new-comers to the sector which lead into updated experiences that offer viewpoint at the wide selection of questions that may be addressed through EPR.

Key Features:
Free Radicals in drugs

Radicals in vivo and in version structures, and their research through Spin Trapping

In vivo EPR, together with Oximetry and Imaging

Time area EPR at Radio Frequencies

EPR of Copper Complexes: movement and Frequency Dependence

Time area EPR and Electron Spin Echo Envelope Modulation

About the Editors:

Prof. Sandra S. Eaton is John Evans Professor within the division of Chemistry and Biochemistry on the college of Denver. Her learn pursuits comprise distance measurements in proteins, EPR of steel ions in organic platforms, electron spin rest instances, and EPR instrumentation. The Eatons co-organize an annual EPR Symposium in Denver.

Prof. Gareth R. Eaton is John Evans Professor within the division of Chemistry and Biochemistry on the college of Denver. His learn pursuits comprise EPR instrumentation, distance measurements in proteins, EPR of steel ions in organic structures, and electron spin rest instances.

Dr. Lawrence J. Berliner is presently Professor and Chair of the dep. of Chemistry and Biochemistry on the collage of Denver after retiring from Ohio kingdom collage, the place he spent a 32-year occupation within the sector of organic magnetic resonance (EPR and NMR). he's the sequence Editor for organic Magnetic Resonance, which he introduced in 1979.

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Extra resources for Biomedical EPR, Part A: Free Radicals, Metals, Medicine, and Physiology

Sample text

The nitrofurantoin-catalyzed reduction of oxygen to superoxide and the hydrogen peroxide that forms from this superoxide may be responsible for some of the toxic manifestations that occur during nitrofurantoin therapy (Mason and Holtzman‚ 1975b). For instance‚ the occasional cases of pulmonary edema and fibrosis caused by nitrofurantoin therapy are similar to the effects of paraquat poisoning. ‚ 1979). Boyd and coworkers (1979) have shown that the acute toxicity of nitrofurantoin is markedly increased by vitamin E deficiency‚ an oxygenenriched atmosphere‚ or a diet high in highly polyunsaturated fats.

I suspect that it was Helmut Beinert’s comments during the site visit that saved the day‚ making the point that in Jim‚ we had a priceless asset for the development and application of EPR to biological studies. At the time‚ Helmut was well known in biologically-oriented EPR circles‚ through his success in using EPR to study enzymes‚ particularly iron- and coppercontaining enzymes‚ and related proteins. He was also known as distinguished participant and lecturer at the Varian EPR-workshops‚ which were very popular.

1986). ‚ 1991). 2 Nitrofurantoin In early investigations of the mechanism of rat hepatic mitochondria! and microsomal nitroreductase (Mason and Holtzman‚ 1975 a)‚ ESR and kinetic evidence demonstrated that the first step in these nitroreductase reactions is the transfer of a single electron to nitro compounds to give the corresponding nitro anion free radical. ‚ 1987‚ 1988a). Nitrofurantoin increased the NADPH-supported oxygen consumption by pulmonary microsomes sevenfold over the basal rate‚ and this stimulation was partially reversed by superoxide dismutase.

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