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Analogue-based Drug Discovery II, Volume 2 by János Fischer, C. Robin Ganellin

By János Fischer, C. Robin Ganellin

Born out of a venture of the IUPAC's committee on Medicinal Chemistry and Drug improvement, this reference addresses prior and present concepts for winning drug analog improvement, extending the formerly released quantity by means of 9 new analog periods and 8 case stories. Like its precursor, this quantity additionally includes a basic part discussing universally appropriate suggestions for analog discovery and improvement. Spanning a variety of healing fields and chemical sessions, the 2 volumes jointly represent the 1st systematic method of drug analog development.Of curiosity to nearly each researcher operating in drug discovery and pharmaceutical chemistry.

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8 Promethazine and chlorpromazine. 1 First Generation “Typical” Antipsychotic Drugs (Other Names: Neuroleptics, Conventional Antipsychotics) Chlorpromazine, the first antipsychotic drug, was obtained from the antihistaminic and sedative promethazine. Charpentier et al. [31] synthesized and Courvoisier et al. 8). Chlorpromazine was marketed by Rhône-Poulenc in 1952. Chlorpromazine initiated an analogue-based drug research, and several direct analogues were discovered and introduced as antipsychotic drugs without the knowledge of their mechanism of action.

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